Verlander's placement on the injured list goes back to his Opening Day start, when he left the game after experiencing some tenderness in his arm.
In addition to placing Verlander on the injured list, the Astros optioned infielder Taylor Jones and recalled right-handed pitchers Nivaldo Rodriguez and Brandon Bielak.
Without Verlander, the Astros are going to rely more on Lance McCullers Jr., Zack Greinke, Josh James, Framber Valdez, and a group of largely unproven relievers aside from Ryan Pressly and closer Roberto Osuna.
They are already without Jose Urquidy, who was projected to be the No. 4 starter in spring training before it was shut down by the COVID-19 pandemic.
Urquidy was not able to participate in summer camp, placed on the injured list as well, and will train in Corpus Christi until he's ready to retun to the big league squad. Reigning American League Rookie of the Year is similarly situated to Urquidy.
Astros third baseman Alex Bregman said the loss of Verlander is tough, both as a pitcher and a teammate.
"We're going to have to just battle and guys are going to have to step up," Bregman said Sunday.
Reliever Chris Devenski, who gave up three runs in the eight inning of Sunday's 7-6 loss to the Seattle Mariners, said after the game he believes the Astros can survive without Verlander, if necessary.
"We have the right guys to get the job and to step up and to go out there and compete the way we know how to," Devenski said. "So we've got to come together as a team, and as we continue to roll day by day, see where we're at, continue to grow. We've got guys who can get the job done."