ISP identified the officer as Nicholas Hopkins, who was transported to St. Louis University Hospital after he was shot in the 1400 block of North 42nd Street, according to police.
Hopkins, 33, was a 10-year veteran of the ISP and was a native of Waterloo, Ill.
Three suspects are in custody, police said.
The shooting Friday, was the second of an Illinois State trooper this month.
A suburban Chicago man has been charged with attempted murder for shooting and wounding an Illinois state trooper who was serving a warrant at the man's home.
The wounded trooper was with other officers attempting to serve the warrant Aug. 15 at the home of Volodymyr Dragan, 43, of Wheeling when someone inside fired shots, striking a trooper in the arm. Dragan is being held without bond.
The officer was taken to a nearby hospital with injuries that weren't life-threatening.
In addition to attempted murder, Dragan also is charged with aggravated battery with a firearm to a police officer, aggravated unlawful restraint and aggravated assault of a police officer.