It's 240 miles from the Pentagon to Ground Zero, and teams will do 80 to 90 miles per day to complete the trip in three days. Bikers will do 199 miles in two days from Washington to the Flight 93 National Memorial in Shanksville.
"It's not a race. I want to make that very clear," Jennifer Depoto said. "The whole idea is to remember who was lost that day on 9/11 in 2001."
Each runner can run as much or as little of the trip as they want because it's a relay style run, meaning one person can do five miles then meet with the rest of the group up the road, and the next person runs while the last runner rests.
They will be making stops at firehouses to eat, drink and sleep along the journey, and Ladder 5 in Philly is one of their stops.
"We actually have an entire team of firefighters from Philly that are going to run with us from Elkton, Maryland all the way to Trenton," she said.
And all of the cadets from the Philadelphia Fire Academy will run with them on Broad Street.
Depoto says anyone is welcome to join and run for as long as they'd like, Forrest Gump style.
"Hey, the more the merrier," she said.
So far, the organization has raised more than $50,000 to give college scholarships to the children of 9/11 victims.