The crash happened Saturday night on Bustleton Avenue near Red Lion Road. Police say the driver of a Chevy Camaro hit two vehicles that triggered a chain reaction.
A man and woman inside a flipped car died at the scene.
They have been identified as 48-year-old Carmen Montalvo Ruiz and 50-year-old Juan Lopez Rivera.
Five other people were rushed to the hospital.
Police are also searching for a person driving a white Lexus, who they say helped the driver leave the scene.