The tents, tattered furniture and other dreary conditions along Emerald Street near Lehigh Avenue have been a symbol of the powerful grip of opioids.
Harry Tapia, who lives nearby, said something had to be done for the neighborhood.
"Dealing with all of the violence and unsanitary conditions has really affected the quality of life," he said, adding, "Nobody should be living in those conditions in the cold."
Although the encampment is closed, Liz Hersh, the city's director of the Office of Homeless Services, said their work doesn't end.
"I know for me it was hard," he admitted. "It was a hard road being out there. I just want to thank everybody who's been a part of helping me and helping my friends out there."