The Texans traded their top wide receiver in DeAndre Hopkins, who was Watson's primary target in his first three seasons.
Carlos Hyde, last year's leading rusher for Houston, is now competing for snaps in Seattle.
And of course, there is first-year play caller Tim Kelly, who Watson has already worked with in previous years.
The Texans' roster turnover, particularly on the offensive side of the ball, is hard to ignore.
The only other offensive starters remaining from Watson's rookie year are center Nick Martin and Will Fuller, who could step up to become the No. 1 receiving option but is known to miss time with nagging injuries.
From the starters two seasons ago, only Martin, Fuller, tight end Jordan Thomas and right guard Zach Fulton remain.
Then take a look at management. The Texans essentially had three different general managers in Watson's first three seasons -- Rick Smith (who traded up to draft Watson 12th overall in 2017), Brian Gaine and now Bill O'Brien doubling up his head coaching duties.
How does all of this change and inconsistency help or hurt their chances of winning? What's the value of continuity, consistency and planning when it comes to maximizing a talent like Watson?
Former Oilers quarterback and Hall of Famer Warren Moon talked on the afternoon show with Ron Hughley and Cecil Shorts III about this very issue.
"So as long as the Houston Texans stop making all these changes that they're making, I think they'll be able to create some of that same continuity that will help Deshaun win a championship."
Moon added that the Texans have a really good group of four receivers to spread the ball around to in Fuller, Brandin Cooks, Randall Cobb and Kenny Stills. If running back David Johnson can channel who he was with Arizona in 2016, that could be a huge addition.
The offensive line is also much improved.
"If they can kind of try and keep this group together for a little while, I think he's got a chance," Moon said. "That would be my question to Bill, or whoever is running the personnel part of the football team. Do you think we're there yet -- is this a group that we think we can work with here for a while?"