Hopkins, in his seventh season for the Texans, would make his fourth Pro Bowl and third straight.
Hopkins is the league's second-leading receiver (1,142 yards), behind only Saints receiver Michael Thomas (1,424 yards), who is the top vote-getter for wideouts league wide.
Thomas received 371,365 votes. Hopkins received 275,684 votes.
The Texans receiver is coming off a masterful performance in a win against the Titans. He led the team with six catches on eight targets for, 119 yards.
Hopkins' biggest catches came in the fourth quarter, with the Texans leading by a touchdown and trying to make it a two-score game.
Deshaun Watson found Hopkins for a 35-yard reception, then again two plays later for a 25-yard play, which set the Texans up with a field goal to separate them from the Titans.