Watson (back) has been limited in practice this week.
He told reporters Thursday he felt fine and did not want to take the day off, despite the Texans already clinching the AFC South title and a spot in the postseason.
Inside linebacker Benardrick McKinney was cleared from the concussion protocol after missing last week's win against the Tampa Bay Buccaneers. Outside linebacker Brennan Scarlett (Achilles) was a full participant in practice Friday after being limited earlier in the week.
Will Fuller V (groin) was ruled out for Sunday's game.
For the Titans, cornerback Adoree Jackson (foot); and wide receivers Adam Humphries (ankle) and Kalif Raymond (concussion) have been ruled out.
Wide receiver Cody Hollister (ankle) is listed as questionable.
The Texans host the Titans on Sunday at 3:25 p.m.