Under normal circumstances, when teams have back-to-back games on opposite coasts, they stay there for the week in order to not make four cross-country flights in a week.
This season due to COVID-19 that may be a challenge.
According to NBC Sports' Peter King, the NFL is going to "strongly urge" teams not to stay on the road for longer periods of time, which likely means encouraging teams to return home after games and then fly back across the country for the following weekend.
This would impact the Patriots in a big way as they are scheduled to take on the Chargers Dec. 6 and then the Rams the following Thursday, Dec. 10. It would be a huge inconvenience, and not make any sense, for the team to fly home Sunday night and then return to L.A. Wednesday.
The report does say teams can file IDER (infectious disease emergency response plans) that need to get approved by the league and union in order for a team to stay on the road for an extended period of time. The Patriots are not the only team with back-to-back games on the opposite coast, either.
Also, when playing games across the country some teams like to get there two days ahead of time to adjust to the time change. That also may not be allowed.