The Patriots' secondary took a hit on Saturday before Sunday's game against the Bills.
Cornerback Stephon Gilmore and safety Kyle Dugger have been downgraded to out, in addition to offensive lineman Justin Herron.
With Gilmore and Dugger out, Joejuan Williams, Terrence Brooks, Jonathan Jones and Jason McCourty will likely see more playing time than they are used to. Dugger has been on the injury report the last few weeks, while Gilmore suffered the injury in practice Thursday and reportedly needed a MRI.
Carl Davis, N'Keal Harry and Julian Edelman have already been ruled out for the game.
Kickoff is set for 1 p.m.