The Maple Leafs said in a statement that Muzzin will remain in quarantine within the hotel and “look to rejoin his teammates upon recovery.”
Muzzin was injured late in the third period of Toronto’s 3-0 win over Columbus on Tuesday.
With the Leafs killing a penalty, Muzzin took a crosscheck from Columbus center Pierre-Luc Dubois before stumbling and jamming his head/neck into the leg of Blue Jackets winger Oliver Bjorkstrand.
Muzzin couldn’t get up after the collision and had to be taken off the ice on a stretcher.
The best-of-five series, which is tied 1-1, resumes Thursday night at Scotiabank Arena.